Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. [electronic resource]
Producer: 20071129Description: 4072-9 p. digitalISSN:- 1078-0432
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase -- genetics
- 5-alpha Reductase Inhibitors
- Administration, Oral
- Animals
- Azasteroids -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chromatography, Liquid -- methods
- Dihydrotestosterone -- administration & dosage
- Disease Models, Animal
- Dutasteride
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- administration & dosage
- Finasteride -- administration & dosage
- Gene Expression Profiling
- Humans
- Male
- Mass Spectrometry -- methods
- Mice
- Mice, Nude
- Molecular Conformation
- Prostatic Neoplasms -- drug therapy
- Protein Isoforms -- antagonists & inhibitors
- RNA, Messenger -- antagonists & inhibitors
- Rats
- Reverse Transcriptase Polymerase Chain Reaction -- methods
- Structure-Activity Relationship
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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