Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix. [electronic resource]
Producer: 20071109Description: 3470-7 p. digitalISSN:- 1078-0432
- Animals
- Antibodies, Monoclonal -- immunology
- Antigen-Antibody Reactions
- Binding Sites
- Carcinoma, Renal Cell -- drug therapy
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase 2 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- biosynthesis
- Dipeptidyl Peptidase 4 -- biosynthesis
- Dipeptidyl-Peptidase IV Inhibitors
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Extracellular Matrix -- drug effects
- Female
- G1 Phase -- drug effects
- Humans
- Kidney Neoplasms -- drug therapy
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phosphorylation -- drug effects
- Retinoblastoma Protein -- metabolism
- S Phase -- drug effects
- Structure-Activity Relationship
- Transplantation, Heterologous
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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