Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. [electronic resource]
Producer: 20060727Description: 5875-82 p. digitalISSN:- 0008-5472
- Acetylation -- drug effects
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Biomarkers, Tumor -- metabolism
- CHO Cells
- Carrier Proteins -- biosynthesis
- Cricetinae
- Drug Synergism
- Enzyme Inhibitors -- administration & dosage
- Folate Receptors, GPI-Anchored
- Folic Acid Antagonists -- administration & dosage
- Histone Deacetylase Inhibitors
- Histones -- metabolism
- Humans
- Hydroxamic Acids -- administration & dosage
- Leukemia, Myeloid, Acute -- drug therapy
- Promoter Regions, Genetic -- drug effects
- RNA, Messenger -- biosynthesis
- Receptors, Cell Surface -- biosynthesis
- Receptors, Immunologic -- metabolism
- Receptors, Retinoic Acid -- biosynthesis
- Substrate Specificity
- Tetrahydrofolates -- administration & dosage
- Transcription Factor AP-1 -- metabolism
- Tretinoin -- administration & dosage
- Up-Regulation -- drug effects
- Valproic Acid -- administration & dosage
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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