Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A. [electronic resource]
Producer: 20060907Description: 161-73 p. digitalISSN:- 1044-7431
- Animals
- Antibodies -- immunology
- Cells, Cultured
- Cerebrospinal Fluid -- immunology
- Disease Models, Animal
- Down-Regulation -- drug effects
- Endocytosis -- drug effects
- Female
- Growth Inhibitors -- antagonists & inhibitors
- Injections, Spinal
- Macaca fascicularis
- Male
- Myelin Proteins -- antagonists & inhibitors
- Nerve Regeneration -- drug effects
- Neurons -- drug effects
- Nogo Proteins
- Oligodendroglia -- drug effects
- Rats
- Rats, Inbred F344
- Rats, Inbred Lew
- Spinal Cord -- cytology
- Spinal Cord Injuries -- drug therapy
- Subarachnoid Space -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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