Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. [electronic resource]
Producer: 20060907Description: 621-3 p. digitalISSN:- 1078-8956
- Amyloid Precursor Protein Secretases
- Animals
- Apoptosis
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- Brain -- cytology
- Brain Ischemia -- metabolism
- Cells, Cultured
- Endopeptidases -- genetics
- Enzyme Inhibitors -- metabolism
- Humans
- Leukocytes -- metabolism
- Mice
- Mice, Knockout
- Mice, Transgenic
- Microglia -- metabolism
- Neurons -- cytology
- Peptides -- genetics
- Rats
- Receptor, Notch1 -- genetics
- Reperfusion Injury
- Signal Transduction -- physiology
- Stroke -- metabolism
- Treatment Outcome
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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