Ex vivo culture with interleukin (IL)-12 improves CD8(+) T-cell adoptive immunotherapy for murine leukemia independent of IL-18 or IFN-gamma but requires perforin. [electronic resource]
Producer: 20060705Description: 4913-21 p. digitalISSN:- 0008-5472
- Acute Disease
- Animals
- CD8-Positive T-Lymphocytes -- drug effects
- Cell Line, Tumor
- Cytotoxicity, Immunologic
- Drug Synergism
- Epitopes, T-Lymphocyte -- immunology
- Female
- Immunotherapy, Adoptive -- methods
- Interferon-gamma -- deficiency
- Interleukin-12 -- immunology
- Interleukin-18 -- immunology
- Leukemia, Myeloid -- immunology
- Lymphocyte Activation
- Male
- Membrane Glycoproteins -- deficiency
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Perforin
- Pore Forming Cytotoxic Proteins
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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