RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts. An autocrine negative feedback mechanism triggered by RANKL-induced interferon-beta via NF-kappaB that restrains osteoclastogenesis and bone resorption. [electronic resource]
Producer: 20060823Description: 15809-20 p. digitalISSN:- 0021-9258
- Animals
- Base Sequence
- Bone Resorption
- Carrier Proteins -- physiology
- Cell Line
- DNA Primers
- Enzyme Inhibitors -- pharmacology
- Interferon-beta -- biosynthesis
- Membrane Glycoproteins -- physiology
- Mice
- NF-kappa B -- metabolism
- Nitric Oxide -- biosynthesis
- Nitric Oxide Synthase Type II -- antagonists & inhibitors
- Osteoclasts -- enzymology
- RANK Ligand
- Receptor Activator of Nuclear Factor-kappa B
- Reverse Transcriptase Polymerase Chain Reaction
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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