Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats. [electronic resource]
Producer: 20061020Description: 209-17 p. digitalISSN:- 0033-3158
- 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors
- Animals
- Antidepressive Agents -- pharmacology
- Behavior, Animal -- drug effects
- Binding, Competitive
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Male
- Phosphodiesterase Inhibitors -- pharmacology
- Radioligand Assay
- Rats
- Rats, Sprague-Dawley
- Rolipram -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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