Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. [electronic resource]
Producer: 20060831Description: 1136-44 p. digitalISSN:- 0090-9556
- ATP Binding Cassette Transporter, Subfamily B -- genetics
- ATP-Binding Cassette Transporters -- genetics
- Animals
- Antimalarials -- pharmacokinetics
- Biotransformation
- Blood-Brain Barrier -- metabolism
- Brain -- metabolism
- Cell Line
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- genetics
- Dogs
- Enzyme Inhibitors -- pharmacology
- Humans
- Ketoconazole -- pharmacology
- Liver -- metabolism
- Male
- Mice
- Mice, Knockout
- Microsomes, Liver
- Quinacrine -- pharmacokinetics
- Rats
- Rats, Sprague-Dawley
- Recombinant Proteins -- metabolism
- ATP-Binding Cassette Sub-Family B Member 4
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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