Immunization of aged mice with a pneumococcal conjugate vaccine combined with an unmethylated CpG-containing oligodeoxynucleotide restores defective immunoglobulin G antipolysaccharide responses and specific CD4+-T-cell priming to young adult levels. [electronic resource]
Producer: 20060510Description: 2177-86 p. digitalISSN:- 0019-9567
- Adjuvants, Immunologic -- administration & dosage
- Aging -- immunology
- Animals
- Bacterial Proteins -- immunology
- CD4-Positive T-Lymphocytes -- immunology
- CpG Islands -- immunology
- Cytokines -- metabolism
- DNA Methylation
- Epitopes, T-Lymphocyte -- immunology
- Female
- Immunoglobulin G -- biosynthesis
- Immunoglobulin M -- biosynthesis
- Interleukin-10 -- metabolism
- Macrophages, Peritoneal -- metabolism
- Mice
- Mice, Inbred BALB C
- Oligodeoxyribonucleotides -- administration & dosage
- Pneumococcal Vaccines -- administration & dosage
- Polysaccharides -- immunology
- Spleen -- cytology
- Vaccines, Conjugate -- administration & dosage
- Vaccines, DNA -- administration & dosage
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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