Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. [electronic resource]
Producer: 20060428Description: 3019-27 p. digitalISSN:- 0022-1767
- Animals
- Aspartic Acid Endopeptidases -- genetics
- Bacterial Proteins -- genetics
- Cell Line
- Down-Regulation -- immunology
- Humans
- Interferon-gamma -- antagonists & inhibitors
- Interleukin-6 -- deficiency
- Lipopeptides
- Lipoproteins -- physiology
- Macrophages -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Mycobacterium tuberculosis -- enzymology
- Peptides -- pharmacology
- Phosphatidylinositols -- physiology
- Toll-Like Receptor 2 -- agonists
- Virulence
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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