Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells. [electronic resource]
Producer: 20060726Description: F116-21 p. digitalISSN:- 1931-857X
- Angiotensin II -- physiology
- Animals
- Anticholesteremic Agents -- pharmacology
- Blood Glucose -- physiology
- Cells, Cultured
- Collagen Type IV -- metabolism
- Diabetes Mellitus, Experimental -- physiopathology
- Diabetic Nephropathies -- physiopathology
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- Janus Kinase 2
- Male
- Mesangial Cells -- chemistry
- Phosphorylation -- drug effects
- Protein-Tyrosine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Rats
- Rats, Sprague-Dawley
- STAT1 Transcription Factor -- metabolism
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Simvastatin -- pharmacology
- Terpenes -- pharmacology
- rho GTP-Binding Proteins -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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