Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II. [electronic resource]
Producer: 20060524Description: 851-61 p. digitalISSN:- 0006-3592
- Animals
- Antibody-Dependent Cell Cytotoxicity -- immunology
- Antigens, CD20 -- immunology
- B-Lymphocytes -- immunology
- CHO Cells
- Cell Line
- Cell Line, Tumor
- Complement System Proteins -- immunology
- Cricetinae
- Cricetulus
- Cytotoxicity, Immunologic -- immunology
- Genetic Vectors -- genetics
- Glycosylation
- Golgi Apparatus -- enzymology
- Humans
- Immunoglobulin G -- immunology
- Killer Cells, Natural -- immunology
- N-Acetylgalactosaminyltransferases -- genetics
- Oligosaccharides -- analysis
- Protein Engineering -- methods
- Protein Processing, Post-Translational
- Protein Sorting Signals -- genetics
- Receptors, IgG -- metabolism
- Recombinant Fusion Proteins -- genetics
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Transfection
- alpha-Mannosidase -- genetics
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Publication Type: Journal Article
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