Human Jagged 1 mutants cause liver defect in Alagille syndrome by overexpression of hepatocyte growth factor. [electronic resource]
Producer: 20061108Description: 559-68 p. digitalISSN:- 0022-2836
- Alagille Syndrome -- genetics
- Animals
- COS Cells
- Calcium-Binding Proteins -- genetics
- Chlorocebus aethiops
- Cloning, Molecular
- Codon, Nonsense
- Frameshift Mutation
- Gene Dosage
- Gene Expression Regulation
- Hepatocyte Growth Factor -- biosynthesis
- Humans
- Intercellular Signaling Peptides and Proteins -- genetics
- Jagged-1 Protein
- Liver -- metabolism
- Membrane Proteins -- genetics
- RNA, Messenger -- genetics
- Receptors, Notch -- physiology
- Sequence Deletion
- Serrate-Jagged Proteins
- Signal Transduction -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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