Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging. [electronic resource]
Producer: 20060216Description: 263-72 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents -- chemical synthesis
- Enzyme Inhibitors -- chemical synthesis
- Glucose -- chemistry
- Guanine -- analogs & derivatives
- HeLa Cells
- Humans
- In Vitro Techniques
- Iodine Isotopes
- Mice
- Mice, Nude
- Molecular Structure
- O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors
- Structure-Activity Relationship
- Time Factors
- Transplantation, Heterologous
- Xenograft Model Antitumor Assays
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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