Mechanism of toxicity of the branched-chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment. [electronic resource]
Producer: 20060525Description: 113-22 p. digitalISSN:- 0736-5748
- Animals
- Animals, Newborn
- Astrocytes -- drug effects
- Biomarkers
- Blotting, Western -- methods
- Brain -- cytology
- Calcium -- metabolism
- Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone -- pharmacology
- Cell Death -- drug effects
- Cell Survival -- drug effects
- Cells, Cultured
- Cytochromes c -- metabolism
- Dose-Response Relationship, Drug
- Drug Interactions
- Hippocampus -- cytology
- Immunohistochemistry -- methods
- Membrane Potentials -- drug effects
- Mitochondria -- drug effects
- Models, Biological
- Organometallic Compounds
- Oxygen -- metabolism
- Phytanic Acid -- toxicity
- Rats
- Rats, Wistar
- Reactive Oxygen Species -- metabolism
- Refsum Disease -- diagnosis
- Rotenone -- pharmacology
- Synaptosomes -- drug effects
- Time Factors
- Uncoupling Agents -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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