Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. [electronic resource]
Producer: 20060329Description: 63-76 p. digitalISSN:- 0270-7306
- Adaptor Proteins, Signal Transducing
- Animals
- Cells, Cultured
- Diabetes Mellitus, Type 2 -- metabolism
- Glucose -- metabolism
- Humans
- Insulin -- metabolism
- Insulin Receptor Substrate Proteins
- Leucine -- metabolism
- Mice
- Monomeric GTP-Binding Proteins -- metabolism
- Mutation
- Neuropeptides -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoproteins -- analysis
- Phosphorylation -- drug effects
- Protein Kinases -- metabolism
- Proteins -- genetics
- Proto-Oncogene Proteins c-akt -- metabolism
- Ras Homolog Enriched in Brain Protein
- Rats
- Regulatory-Associated Protein of mTOR
- Serine -- metabolism
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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