Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair. [electronic resource]
Producer: 20060511Description: 347-61 p. digitalISSN:- 1568-7864
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases -- metabolism
- Amino Acid Sequence
- Animals
- Base Pair Mismatch -- genetics
- Carrier Proteins -- genetics
- DNA Repair
- DNA Repair Enzymes -- metabolism
- DNA-Binding Proteins -- metabolism
- Embryo, Mammalian -- cytology
- Fibroblasts -- cytology
- Humans
- Mice
- Mismatch Repair Endonuclease PMS2
- Molecular Sequence Data
- MutL Protein Homolog 1
- Mutation
- Nuclear Proteins -- genetics
- Sequence Homology, Amino Acid
- Suppression, Genetic
- Thioguanine -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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