Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV. [electronic resource]
Producer: 20060622Description: 2197-208 p. digitalISSN:- 0968-0896
- Animals
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- Binding Sites
- Binding, Competitive
- Cathepsin D -- antagonists & inhibitors
- Crystallography, X-Ray
- Cyclization
- Drug Design
- Humans
- Macrocyclic Compounds -- chemical synthesis
- Models, Chemical
- Models, Molecular
- Molecular Conformation
- Plasmodium falciparum -- drug effects
- Protease Inhibitors -- chemical synthesis
- Protozoan Proteins
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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