Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway. [electronic resource]
Producer: 20051228Description: 727-34 p. digitalISSN:- 0160-2446
- Animals
- Antioxidants -- therapeutic use
- Berberine -- analogs & derivatives
- Calcium Channel Blockers -- therapeutic use
- Calcium Channels, L-Type -- drug effects
- Endothelin-1 -- antagonists & inhibitors
- Hypertension, Pulmonary -- drug therapy
- Hypertrophy, Right Ventricular -- drug therapy
- Hypoxia -- complications
- Male
- Malondialdehyde -- analysis
- Nitric Oxide -- biosynthesis
- Nitric Oxide Synthase -- metabolism
- Oxidative Stress -- drug effects
- Pulmonary Artery -- pathology
- Rats
- Rats, Sprague-Dawley
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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