A novel mucosal vaccine based on live Lactococci expressing E7 antigen and IL-12 induces systemic and mucosal immune responses and protects mice against human papillomavirus type 16-induced tumors. [electronic resource]
Producer: 20060117Description: 7297-302 p. digitalISSN:- 0022-1767
- Administration, Intranasal
- Animals
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes -- immunology
- Cancer Vaccines -- administration & dosage
- Cell Line, Tumor
- Cell Transplantation
- Disease Models, Animal
- Female
- Human papillomavirus 16 -- immunology
- Immunity, Mucosal -- immunology
- Interleukin-12 -- biosynthesis
- Lactococcus lactis -- genetics
- Mice
- Nasal Mucosa -- immunology
- Neoplasm Transplantation
- Oncogene Proteins, Viral -- biosynthesis
- Papillomavirus E7 Proteins
- Papillomavirus Infections -- prevention & control
- Papillomavirus Vaccines
- Recombinant Proteins -- biosynthesis
- Tumor Virus Infections -- immunology
- Uterine Cervical Neoplasms -- immunology
- Viral Vaccines -- administration & dosage
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Publication Type: Journal Article
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