ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. [electronic resource]
Producer: 20060213Description: 8145-57 p. digitalISSN:- 1078-0432
- Animals
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Central Nervous System Neoplasms -- drug therapy
- Dose-Response Relationship, Drug
- Ependymoma -- drug therapy
- ErbB Receptors -- antagonists & inhibitors
- Glioma -- drug therapy
- Humans
- Immunohistochemistry
- Ki-67 Antigen -- analysis
- Mice
- Mice, Nude
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Neovascularization, Pathologic -- metabolism
- Phosphorylation -- drug effects
- Piperidines -- pharmacology
- Quinazolines -- pharmacology
- Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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