Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. [electronic resource]
Producer: 20060118Description: 10545-54 p. digitalISSN:- 0008-5472
- Calcium Channels -- metabolism
- Doxorubicin -- pharmacology
- Drug Synergism
- Enzyme Activation
- Glycogen Synthase Kinase 3 -- metabolism
- Glycogen Synthase Kinase 3 beta
- HeLa Cells
- Hexokinase -- antagonists & inhibitors
- Humans
- Mitochondria -- metabolism
- Paclitaxel -- pharmacology
- Peptide Fragments -- pharmacology
- Phosphorylation
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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