Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity. [electronic resource]
Producer: 20060117Description: 7198-207 p. digitalISSN:- 0022-2623
- Acridines -- chemical synthesis
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Cytochrome P-450 Enzyme System -- metabolism
- Drug Screening Assays, Antitumor
- Drug Stability
- Flow Cytometry
- Heterocyclic Compounds, 4 or More Rings -- chemical synthesis
- Humans
- In Vitro Techniques
- Microscopy, Confocal
- Microsomes, Liver -- drug effects
- Rats
- Stereoisomerism
- Structure-Activity Relationship
- Telomerase -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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