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  2. Details for: 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
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4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. [electronic resource]

By:
  • Churcher, Ian
Contributor(s):
  • Beher, Dirk
  • Best, Jonathan D
  • Castro, José L
  • Clarke, Earl E
  • Gentry, Amy
  • Harrison, Timothy
  • Hitzel, Laure
  • Kay, Euan
  • Kerrad, Sonia
  • Lewis, Huw D
  • Morentin-Gutierrez, Pablo
  • Mortishire-Smith, Russell
  • Oakley, Paul J
  • Reilly, Michael
  • Shaw, Duncan E
  • Shearman, Mark S
  • Teall, Martin R
  • Williams, Susie
  • Wrigley, Jonathan D J
Producer: 20060302Description: 280-4 p. digitalISSN:
  • 0960-894X
Subject(s):
  • Administration, Oral
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides -- drug effects
  • Animals
  • Aspartic Acid Endopeptidases
  • Brain -- drug effects
  • Cyclohexanes -- administration & dosage
  • Dose-Response Relationship, Drug
  • Endopeptidases -- drug effects
  • Enzyme Inhibitors -- chemical synthesis
  • Mice
  • Molecular Structure
  • Peptide Fragments -- drug effects
  • Structure-Activity Relationship
  • Sulfones -- administration & dosage
  • Time Factors
Online resources:
  • Available from publisher's website
In: Bioorganic & medicinal chemistry letters vol. 16
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Publication Type: Journal Article

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4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.

APA

Churcher I., Beher D., Best J. D., Castro J. L., Clarke E. E., Gentry A., Harrison T., Hitzel L., Kay E., Kerrad S., Lewis H. D., Morentin-Gutierrez P., Mortishire-Smith R., Oakley P. J., Reilly M., Shaw D. E., Shearman M. S., Teall M. R., Williams S. & Wrigley J. D. J. (20060302). 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. : Bioorganic & medicinal chemistry letters.

Chicago

Churcher Ian, Beher Dirk, Best Jonathan D, Castro José L, Clarke Earl E, Gentry Amy, Harrison Timothy, Hitzel Laure, Kay Euan, Kerrad Sonia, Lewis Huw D, Morentin-Gutierrez Pablo, Mortishire-Smith Russell, Oakley Paul J, Reilly Michael, Shaw Duncan E, Shearman Mark S, Teall Martin R, Williams Susie and Wrigley Jonathan D J. 20060302. 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. : Bioorganic & medicinal chemistry letters.

Harvard

Churcher I., Beher D., Best J. D., Castro J. L., Clarke E. E., Gentry A., Harrison T., Hitzel L., Kay E., Kerrad S., Lewis H. D., Morentin-Gutierrez P., Mortishire-Smith R., Oakley P. J., Reilly M., Shaw D. E., Shearman M. S., Teall M. R., Williams S. and Wrigley J. D. J. (20060302). 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. : Bioorganic & medicinal chemistry letters.

MLA

Churcher Ian, Beher Dirk, Best Jonathan D, Castro José L, Clarke Earl E, Gentry Amy, Harrison Timothy, Hitzel Laure, Kay Euan, Kerrad Sonia, Lewis Huw D, Morentin-Gutierrez Pablo, Mortishire-Smith Russell, Oakley Paul J, Reilly Michael, Shaw Duncan E, Shearman Mark S, Teall Martin R, Williams Susie and Wrigley Jonathan D J. 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. : Bioorganic & medicinal chemistry letters. 20060302.

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