Osteoclasts from patients with autosomal dominant osteopetrosis type I caused by a T253I mutation in low-density lipoprotein receptor-related protein 5 are normal in vitro, but have decreased resorption capacity in vivo. [electronic resource]
Producer: 20060126Description: 1341-8 p. digitalISSN:- 0002-9440
- Adult
- Amino Acid Substitution
- Bone Resorption -- physiopathology
- Carrier Proteins -- pharmacology
- Cell Differentiation
- Female
- Genes, Dominant
- Humans
- LDL-Receptor Related Proteins -- genetics
- Lipopolysaccharide Receptors -- analysis
- Low Density Lipoprotein Receptor-Related Protein-5
- Macrophage Colony-Stimulating Factor -- pharmacology
- Male
- Membrane Glycoproteins -- pharmacology
- Middle Aged
- Monocytes
- Mutation
- Osteoclasts -- physiology
- Osteopetrosis -- genetics
- RANK Ligand
- Receptor Activator of Nuclear Factor-kappa B
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Publication Type: Journal Article
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