Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation. [electronic resource]
Producer: 20060207Description: 41439-48 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Anisoles -- chemistry
- Antineoplastic Agents -- pharmacology
- Blotting, Western
- Bromides -- chemistry
- Cell Line, Tumor
- Cell Membrane -- metabolism
- Cell Movement
- Chromatography, Affinity
- Crk-Associated Substrate Protein -- metabolism
- DNA, Complementary -- metabolism
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Focal Adhesion Protein-Tyrosine Kinases -- metabolism
- HSP27 Heat-Shock Proteins
- Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- Inhibitory Concentration 50
- Intracellular Signaling Peptides and Proteins
- Isoxazoles -- chemistry
- Models, Chemical
- Molecular Chaperones
- Molecular Sequence Data
- Neoplasm Invasiveness
- Neoplasm Proteins -- antagonists & inhibitors
- Neoplasms -- drug therapy
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation
- Protein Binding
- Protein Kinase C -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Protein Structure, Tertiary
- RNA, Small Interfering -- chemistry
- Time Factors
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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