Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1. [electronic resource]
Producer: 20051214Description: 8927-35 p. digitalISSN:- 0008-5472
- Antibiotics, Antineoplastic -- antagonists & inhibitors
- Cell Line, Tumor
- Cellular Senescence -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- antagonists & inhibitors
- DNA-Binding Proteins -- metabolism
- Down-Regulation
- Doxorubicin -- antagonists & inhibitors
- Drug Resistance, Neoplasm
- Fibrosarcoma -- drug therapy
- G2 Phase -- drug effects
- Humans
- Kruppel-Like Transcription Factors
- Mitosis -- physiology
- Polyploidy
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-myc -- antagonists & inhibitors
- STAT3 Transcription Factor -- metabolism
- Transcription Factors -- metabolism
- Tumor Suppressor Protein p53 -- metabolism
- src-Family Kinases -- biosynthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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