Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. [electronic resource]
Producer: 20060725Description: 426-38 p. digitalISSN:- 0887-2333
- Animals
- Aryl Hydrocarbon Hydroxylases -- biosynthesis
- Benzo(a)pyrene -- toxicity
- Biotransformation
- Carcinogens -- toxicity
- Cytochrome P-450 CYP1A1 -- biosynthesis
- Cytochrome P-450 CYP1B1
- Dose-Response Relationship, Drug
- Enzyme Induction
- Gene Expression -- drug effects
- In Vitro Techniques
- Injections, Intraperitoneal
- Liver -- drug effects
- Lung -- drug effects
- Male
- Polychlorinated Dibenzodioxins -- toxicity
- RNA, Messenger -- metabolism
- Rats
- Rats, Sprague-Dawley
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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