Targeted mutation of key residues at the start of helix 12 in the hERalpha ligand-binding domain identifies the role of hydrogen-bonding and hydrophobic interactions in the activity of the protein. [electronic resource]
Producer: 20060323Description: 1-11 p. digitalISSN:- 0960-0760
- Binding Sites
- Estradiol -- pharmacology
- Estrogen Antagonists -- pharmacology
- Estrogen Receptor alpha -- chemistry
- Estrogen Receptor beta -- chemistry
- HeLa Cells
- Humans
- Hydrogen Bonding
- Hydrophobic and Hydrophilic Interactions
- Ligands
- Models, Molecular
- Mutation
- Promoter Regions, Genetic -- genetics
- Protein Binding
- Protein Conformation
- Protein Structure, Tertiary
- Response Elements -- genetics
- Tamoxifen -- analogs & derivatives
- Transcription Factor AP-1 -- metabolism
- Transcriptional Activation
- Two-Hybrid System Techniques
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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