Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action. [electronic resource]
Producer: 20051017Description: 11067-73 p. digitalISSN:- 0006-2960
- Amino Acid Substitution -- genetics
- Animals
- Binding Sites -- genetics
- Blood Glucose -- drug effects
- Chelating Agents -- administration & dosage
- Diabetes Mellitus, Experimental -- drug therapy
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme Activation -- drug effects
- Galactosamine -- administration & dosage
- Hydrogen Bonding -- drug effects
- Inositol -- administration & dosage
- Inositol Phosphates -- administration & dosage
- Insulin -- administration & dosage
- Male
- Manganese -- chemistry
- Models, Molecular
- Nitrophenols -- chemistry
- Organophosphorus Compounds -- chemistry
- Phosphoprotein Phosphatases -- chemistry
- Point Mutation
- Protein Binding -- genetics
- Protein Phosphatase 2C
- Protein Structure, Tertiary -- genetics
- Rats
- Rats, Sprague-Dawley
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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