Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor-G protein coupling and Gbetagamma signaling. [electronic resource]
Producer: 20051201Description: 247-61 p. digitalISSN:- 0306-4522
- Adenylyl Cyclases -- metabolism
- Analgesics, Opioid -- pharmacology
- Animals
- Blotting, Western
- Drug Tolerance
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- -- pharmacology
- GTP-Binding Protein alpha Subunits -- metabolism
- GTP-Binding Protein beta Subunits -- physiology
- GTP-Binding Protein gamma Subunits -- physiology
- Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism
- Hot Temperature
- Immunoprecipitation
- Isoenzymes -- metabolism
- Male
- Naloxone -- pharmacology
- Narcotic Antagonists -- pharmacology
- Opioid-Related Disorders -- prevention & control
- Pain Threshold -- drug effects
- Protein Binding -- drug effects
- Rats
- Rats, Sprague-Dawley
- Reaction Time -- drug effects
- Receptors, G-Protein-Coupled -- drug effects
- Receptors, Opioid, mu -- drug effects
- Signal Transduction -- drug effects
- Substance Withdrawal Syndrome -- prevention & control
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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