IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. [electronic resource]
Producer: 20051130Description: 2630-4 p. digitalISSN:- 0022-1767
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Autoimmune Diseases -- enzymology
- Carrier Proteins -- genetics
- Caspase 1 -- biosynthesis
- Caspase Inhibitors
- Cold Temperature -- adverse effects
- Cysteine Proteinase Inhibitors -- pharmacology
- Cytokines -- metabolism
- Drug Evaluation, Preclinical
- Female
- Humans
- Hypersensitivity -- enzymology
- Inflammation -- enzymology
- Interleukin-1 -- antagonists & inhibitors
- Lipopolysaccharides -- pharmacology
- Male
- Middle Aged
- Monocytes -- enzymology
- NLR Family, Pyrin Domain-Containing 3 Protein
- Prodrugs -- pharmacology
- Protein Precursors -- biosynthesis
- Syndrome
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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