Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors. [electronic resource]
Producer: 20060105Description: 5487-95 p. digitalISSN:- 1078-0432
- Adult
- Aged
- Antineoplastic Agents -- therapeutic use
- Area Under Curve
- Deoxyuridine -- blood
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- therapeutic use
- Female
- Genotype
- Glutarates -- therapeutic use
- Homocysteine -- blood
- Humans
- Infusions, Intravenous
- Isoindoles
- Liposomes -- metabolism
- Male
- Maximum Tolerated Dose
- Middle Aged
- Neoplasms -- drug therapy
- Polymorphism, Genetic
- Quinazolines -- therapeutic use
- Sepsis
- Thymidylate Synthase -- antagonists & inhibitors
- Time Factors
- Treatment Outcome
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Publication Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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