Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation. [electronic resource]
Producer: 20051004Description: 6601-11 p. digitalISSN:- 0008-5472
- Animals
- Benzothiazoles
- Cell Line
- Down-Regulation
- Epidermis -- enzymology
- JNK Mitogen-Activated Protein Kinases -- metabolism
- MAP Kinase Signaling System
- Mice
- NF-kappa B -- physiology
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases -- biosynthesis
- Phosphorylation -- radiation effects
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- RNA, Small Interfering -- genetics
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Thiazoles -- pharmacology
- Toluene -- analogs & derivatives
- Transcription Factor AP-1 -- physiology
- Transfection
- Tumor Suppressor Protein p53 -- antagonists & inhibitors
- Tumor Suppressor Proteins -- biosynthesis
- Ultraviolet Rays
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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