E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short). [electronic resource]
Producer: 20060323Description: 260-72 p. digitalISSN:- 1350-9047
- Adenocarcinoma -- chemistry
- Apoptosis
- Apoptosis Regulatory Proteins -- pharmacology
- Blotting, Western
- CASP8 and FADD-Like Apoptosis Regulating Protein
- Caspase 8
- Caspases -- metabolism
- Cell Line, Tumor
- Cytotoxicity, Immunologic
- DNA -- metabolism
- Down-Regulation
- E2F1 Transcription Factor -- genetics
- Enzyme Activation
- Fas Ligand Protein
- Fluorescent Antibody Technique, Indirect
- Gene Expression Regulation, Neoplastic
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Lung Neoplasms -- chemistry
- Membrane Glycoproteins -- pharmacology
- RNA, Messenger -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- T-Lymphocytes, Cytotoxic -- immunology
- TNF-Related Apoptosis-Inducing Ligand
- Tumor Necrosis Factor-alpha -- pharmacology
- Tumor Necrosis Factors -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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