In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions. [electronic resource]
Producer: 20060804Description: 1628-36 p. digitalISSN:- 0090-9556
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Calmodulin -- antagonists & inhibitors
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP1A2 Inhibitors
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2C8
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP2D6 -- metabolism
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 CYP2E1 -- metabolism
- Cytochrome P-450 CYP2E1 Inhibitors
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Dose-Response Relationship, Drug
- Drug Interactions
- Humans
- In Vitro Techniques
- Indazoles -- metabolism
- Kinetics
- Microsomes, Liver -- enzymology
- Mixed Function Oxygenases -- metabolism
- Recombinant Proteins -- metabolism
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Publication Type: Comparative Study; Journal Article
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