Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. [electronic resource]
Producer: 20050914Description: 6401-8 p. digitalISSN:- 0008-5472
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Benzoquinones
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Line, Tumor
- Cyclin D1 -- metabolism
- Cysteine Proteinase Inhibitors -- pharmacology
- ErbB Receptors -- genetics
- Gene Deletion
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- Lactams, Macrocyclic
- Lung Neoplasms -- drug therapy
- Mice
- Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors
- NIH 3T3 Cells
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein Structure, Tertiary
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt
- Quinones -- pharmacology
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
There are no comments on this title.
Log in to your account to post a comment.