Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. [electronic resource]
Producer: 20051213Description: 1978-87 p. digitalISSN:- 0143-3334
- Antineoplastic Agents, Phytogenic -- pharmacology
- Ataxia Telangiectasia -- metabolism
- Ataxia Telangiectasia Mutated Proteins
- CDC2 Protein Kinase -- metabolism
- Cell Cycle Proteins -- metabolism
- Checkpoint Kinase 1
- Checkpoint Kinase 2
- DNA-Binding Proteins -- metabolism
- Female
- Humans
- Ovarian Neoplasms -- drug therapy
- Phosphorylation -- drug effects
- Protein Kinases -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Resveratrol
- Ribonucleotide Reductases -- antagonists & inhibitors
- S Phase -- drug effects
- Signal Transduction -- drug effects
- Stilbenes -- pharmacology
- Tumor Cells, Cultured
- Tumor Suppressor Proteins -- metabolism
- Tyrosine -- metabolism
- cdc25 Phosphatases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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