Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90. [electronic resource]
Producer: 20060818Description: 273-85 p. digitalISSN:- 1540-658X
- Animals
- Benzoquinones
- Blotting, Western
- Carrier Proteins -- antagonists & inhibitors
- Cell Extracts -- analysis
- Dose-Response Relationship, Drug
- Drug Design
- Enzyme Inhibitors -- pharmacology
- HCT116 Cells
- HSP70 Heat-Shock Proteins -- antagonists & inhibitors
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- HT29 Cells
- Heterocyclic Compounds, 2-Ring -- pharmacology
- Humans
- Immunoassay -- methods
- Intracellular Signaling Peptides and Proteins
- Lactams, Macrocyclic
- Lymphocytes -- chemistry
- Mice
- Neoplasm Transplantation
- Proto-Oncogene Proteins c-raf -- antagonists & inhibitors
- Pyrazoles -- pharmacology
- Quinones -- pharmacology
- Rifabutin -- analogs & derivatives
- Technology, Pharmaceutical -- methods
- Transplantation, Heterologous
- eIF-2 Kinase -- antagonists & inhibitors
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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