Mutant PIK3CA promotes cell growth and invasion of human cancer cells. [electronic resource]
Producer: 20050906Description: 561-73 p. digitalISSN:- 1535-6108
- Amino Acid Substitution
- Animals
- Apoptosis -- genetics
- Apoptosis Regulatory Proteins
- Base Sequence
- Cell Line, Tumor
- Cell Movement -- genetics
- Cell Proliferation
- Chromones -- pharmacology
- Class I Phosphatidylinositol 3-Kinases
- DNA-Binding Proteins -- genetics
- Enzyme Inhibitors -- pharmacology
- Forkhead Box Protein O1
- Forkhead Box Protein O3
- Forkhead Transcription Factors
- Gene Targeting
- Growth Substances -- deficiency
- Humans
- Insulin -- deficiency
- Membrane Glycoproteins -- physiology
- Mice
- Mice, Nude
- Morpholines -- pharmacology
- Mutation
- Neoplasm Invasiveness -- genetics
- Neoplasms, Experimental -- genetics
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases -- genetics
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-akt
- Signal Transduction -- drug effects
- TNF-Related Apoptosis-Inducing Ligand
- Transcription Factors -- genetics
- Tumor Necrosis Factor-alpha -- physiology
- Xenograft Model Antitumor Assays -- methods
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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