Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. [electronic resource]
Producer: 20050829Description: 4182-90 p. digitalISSN:- 1078-0432
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Sequence
- Antineoplastic Agents -- pharmacology
- Benzamides
- Blotting, Western
- DNA Mutational Analysis
- Drug Resistance, Neoplasm -- drug effects
- Female
- Gastrointestinal Stromal Tumors -- drug therapy
- Genotype
- Humans
- Imatinib Mesylate
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Piperazines -- pharmacology
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-kit -- genetics
- Pyrimidines -- pharmacology
- Receptor, Platelet-Derived Growth Factor alpha -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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