Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications through protein modeling. [electronic resource]
Producer: 20050823Description: 3668-77 p. digitalISSN:- 1078-0432
- Adult
- Aged
- Amino Acid Sequence
- Antineoplastic Agents -- pharmacology
- Benzamides
- Cell Transformation, Neoplastic
- Crystallography, X-Ray
- DNA Mutational Analysis
- DNA, Neoplasm -- analysis
- Female
- Gastrointestinal Stromal Tumors -- genetics
- Germ-Line Mutation
- Humans
- Imatinib Mesylate
- Male
- Middle Aged
- Models, Chemical
- Molecular Sequence Data
- Pedigree
- Piperazines -- pharmacology
- Platelet-Derived Growth Factor -- biosynthesis
- Protein Conformation
- Proto-Oncogene Proteins c-kit -- biosynthesis
- Pyrimidines -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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