Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. [electronic resource]
Producer: 20050705Description: 881-93 p. digitalISSN:- 1420-682X
- Apoptosis -- drug effects
- CDC2 Protein Kinase -- metabolism
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Caspases -- metabolism
- Cell Cycle -- drug effects
- Cell Cycle Proteins -- metabolism
- Cell Proliferation -- drug effects
- Cells, Cultured
- Checkpoint Kinase 2
- Cyclin-Dependent Kinase Inhibitor p27
- Cytochromes c -- metabolism
- Enzyme Activation -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, bcl-2 -- physiology
- Humans
- Lung Neoplasms -- drug therapy
- Phosphorylation -- drug effects
- Poly(ADP-ribose) Polymerases -- physiology
- Protein Serine-Threonine Kinases -- metabolism
- Sesquiterpenes -- pharmacology
- Tumor Suppressor Proteins -- metabolism
- cdc25 Phosphatases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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