Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. [electronic resource]
Producer: 20050912Description: 25953-9 p. digitalISSN:- 0021-9258
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Cell Death
- Cell Line, Tumor
- Comet Assay
- DNA Damage
- Etoposide -- pharmacology
- Feedback, Physiological
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Humans
- Immunoblotting
- Mutation
- Nuclear Proteins -- chemistry
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases -- physiology
- Phosphorylation
- Promoter Regions, Genetic
- Proto-Oncogene Proteins -- chemistry
- Proto-Oncogene Proteins c-mdm2
- RNA -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Serine -- chemistry
- Time Factors
- Transcription, Genetic
- Transcriptional Activation
- Transfection
- Tumor Suppressor Protein p53 -- chemistry
- Tumor Suppressor Proteins -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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