Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. [electronic resource]
Producer: 20050802Description: 22297-307 p. digitalISSN:- 0021-9258
- Animals
- Apoptosis
- Blotting, Western
- Cell Line
- Cell Survival
- Dose-Response Relationship, Drug
- Down-Regulation
- Forkhead Box Protein O1
- Forkhead Transcription Factors
- Gastric Inhibitory Polypeptide -- chemistry
- Humans
- Immunohistochemistry
- Islets of Langerhans -- cytology
- Luciferases -- metabolism
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Microscopy, Confocal
- Microscopy, Fluorescence
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation
- Promoter Regions, Genetic
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Rats
- Rats, Zucker
- Signal Transduction
- Subcellular Fractions
- Time Factors
- Transcription Factors -- metabolism
- Transcription, Genetic
- bcl-2-Associated X Protein
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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