Acid-triggered membrane insertion of Pseudomonas exotoxin A involves an original mechanism based on pH-regulated tryptophan exposure. [electronic resource]
Producer: 20050712Description: 21194-201 p. digitalISSN:- 0021-9258
- Animals
- Annexin A5 -- chemistry
- Aspartic Acid -- chemistry
- Biotinylation
- Cell Line
- Cell Membrane -- metabolism
- Cell-Free System
- Cesium -- pharmacology
- Chlorides -- pharmacology
- Diphtheria Toxin -- chemistry
- Dose-Response Relationship, Drug
- Endosomes -- metabolism
- Escherichia coli -- metabolism
- Exotoxins -- chemistry
- Hydrogen-Ion Concentration
- Immunotoxins -- chemistry
- Inhibitory Concentration 50
- Kinetics
- Mice
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Protein Conformation
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Protein Transport
- Pseudomonas -- metabolism
- Spectrometry, Fluorescence
- Time Factors
- Tryptophan -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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