Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. [electronic resource]
Producer: 20050712Description: 21321-8 p. digitalISSN:- 0021-9258
- 3-Hydroxysteroid Dehydrogenases -- chemistry
- Allosteric Site
- Amino Acid Sequence
- Androstenols -- chemistry
- Animals
- Arginine -- chemistry
- Baculoviridae -- metabolism
- Blotting, Western
- Catalysis
- Catalytic Domain
- Cell Line
- DNA Primers -- chemistry
- Dihydrotestosterone -- analogs & derivatives
- Dose-Response Relationship, Drug
- Electrophoresis, Polyacrylamide Gel
- Glutamine -- chemistry
- Histidine -- chemistry
- Humans
- Insecta
- Kinetics
- Models, Chemical
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- NAD -- chemistry
- Protein Binding
- Protein Conformation
- Sequence Homology, Amino Acid
- Structure-Activity Relationship
- Substrate Specificity
- Tissue Distribution
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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