Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro. [electronic resource]
Producer: 20050804Description: 56-63 p. digitalISSN:- 0026-2862
- Administration, Oral
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Area Under Curve
- Cell Movement -- drug effects
- Dose-Response Relationship, Drug
- Endothelium, Vascular -- cytology
- Humans
- Kinetics
- Lenalidomide
- Male
- Mesentery -- blood supply
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Rats
- Rats, Sprague-Dawley
- Thalidomide -- administration & dosage
- Umbilical Veins -- cytology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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