Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds. Studies using human acute lymphoblastic leukemia cells and the zebrafish model. [electronic resource]
Producer: 20050415Description: 114-22 p. digitalISSN:- 0004-4172
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Caspase Inhibitors
- Cell Proliferation -- drug effects
- Dideoxynucleotides
- Drug Screening Assays, Antitumor
- Humans
- Jurkat Cells
- Leukemia -- drug therapy
- Magnetic Resonance Spectroscopy
- Nephelometry and Turbidimetry
- Prodrugs -- pharmacology
- Tetrazolium Salts
- Thiazoles
- Thymidine Monophosphate -- analogs & derivatives
- Tubulin -- biosynthesis
- Zebrafish
- Zidovudine -- analogs & derivatives
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Publication Type: Journal Article
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